Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy
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Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy
Striking structural differences between voltage-gated sodium (Nav) channels from prokaryotes (homotetramers) and eukaryotes (asymmetric, four-domain proteins) suggest the likelihood of different molecular mechanisms for common functions. For these two channel families, our data show similar selectivity sequences among alkali cations (relative permeability, Pion/PNa) and asymmetric, bi-ionic rev...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2014
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201311037